Vardenafil Disintegrating Oral Tablet (VARDENAFIL DISINTEGRATING TABLET - ORAL)

Vardenafil should also be withheld in patients with

• Vardenafil should not be taken with fatty foods for quick absorption.
• It is effective for men with erectile dysfunction of various causes.
• The medication is available in tablet form for oral intake.
• The onset of action is typically within 30-60 minutes.
• Use of Vardenafil can improve confidence and intimacy quality.
• It is not meant for daily use but as needed before sex.
• Some may experience prolonged erections; seek help if prolonged.
• Precautions include avoiding grapefruit juice which can affect levels.
• Patients with kidney or liver issues should inform their doctor.
• Sexual activity has inherent cardiovascular risks, which Vardenafil may potentiate.
• Discontinuation should be discussed with a healthcare provider.

known hypersensitivity to the drug or its excipients.

References and Recommended Reading

This product is available solely through our 503A Compounding Pharmacy, ensuring personalized care and precision in every order. Please note that a valid prescription is required for purchase. If you do not have an account, please contact us. Vardenafil tablets are oral solid dosage forms containing vardenafil, a phosphodiesterase type 5 (PDE5) inhibitor used for the treatment of erectile dysfunction. Clinically, vardenafil improves penile hemodynamics by enhancing cyclic guanosine monophosphate (cGMP) signaling, thereby facilitating smooth-muscle relaxation and engorgement of the corpus cavernosum during sexual stimulation.

Potential Interactions: What to Watch Out For:

Pharmacokinetic data derived from clinical and post-marketing studies show that orally administered vardenafil is rapidly absorbed, achieving peak plasma concentrations within 30-120 minutes, with an absolute bioavailability near 15 %. First-pass hepatic metabolism via cytochrome P450 3A4 and, to a lesser extent, CYP 2C isoenzymes, accounts for the relatively modest systemic exposure compared with intravenous dosing. The terminal elimination half-life is approximately 4-6 hours, supporting once-daily on-demand administration rather than continuous dosing. In healthy volunteers, food high in fat delays but does not meaningfully diminish the extent of absorption; however, grapefruit products may significantly alter plasma levels through metabolic inhibition (see Interactions). Because vardenafil undergoes high plasma-protein binding (~95 buy super p force jelly %), clinically significant displacement interactions are theoretically possible but uncommon.

2.2 Pharmacokinetics

For most adult males, the recommended on-demand oral dose is 10 mg administered approximately 60 minutes prior to anticipated sexual activity; however, patient-specific factors often prompt individualized regimens. Clinical experience supports initial titration downward to 5 mg in men ≥ 65 years or in those with moderate hepatic impairment (Child-Pugh B), and upward adjustment to 20 mg in younger, otherwise healthy men who exhibit inadequate response. Dosing frequency should not exceed one dose per 24-hour period to minimize cumulative exposure and adverse events. Patients receiving potent CYP3A4 inhibitors may require maximum doses of 2.5-5 mg no more than once in 72 hours. The erectile response is a neurovascular event initiated by parasympathetic-mediated nitric oxide (NO) release from cavernous nerve terminals and endothelial cells. Electrocardiographic studies revealed small, dose-dependent

increases in QTc (approximately 4-6 ms)

Shipping & Delivery

Absolute contraindications include concurrent use of organic nitrates (e.g., nitroglycerin, isosorbide dinitrate) in any form. Co-administration may lead to severe, potentially life-threatening hypotension owing to additive increases in cGMP-mediated vasodilation. Similarly, patients receiving riociguat, a soluble guanylate-cyclase stimulator, should avoid vardenafil because the combination can produce profound systemic blood-pressure reductions unresponsive to vasopressors. Prescribers must inquire specifically about intermittent nitrate use for angina prior to initiating therapy. Individuals with inherited degenerative retinal disorders such as retinitis pigmentosa, although representing less than one percent of the population, were excluded from pivotal trials; theoretical PDE6 cross-reactivity raises concerns about exacerbating photoreceptor degeneration. at supratherapeutic exposures; consequently, vardenafil

• Vardenafil's active ingredient is vardenafil hydrochloride.
• It is often preferred for its rapid onset compared to others.
• It can be used successfully in men with nerve damage.
• Vardenafil may cause temporary visual color changes.
• It is not suitable for individuals with severe heart failure.
• Alcohol can impair the effectiveness of vardenafil.
• Taking it on an empty stomach may improve absorption.
• Avoid driving or operating machinery after taking Vardenafil.
• It is important to follow-up with your healthcare provider regularly.
• Do not double dose if the first dose is ineffective.
• Use the lowest effective dose to minimize side effects.

is contraindicated in men taking class

This article is cited by

These interactions stabilize the inhibitor-enzyme complex, yielding an inhibitory constant (K_i) in the low nanomolar range. Following oral ingestion of a 20 mg tablet, mean vardenafil C_max approximates 20 ng mL⁻¹, with systemic exposure proportional across a 5-20 mg dose span. Metabolic clearance is dominated by oxidative N-dealkylation and ring hydroxylation, producing an active metabolite (M1) that retains ~28 % of parent potency but constitutes less than 7 % of the circulating molar fraction. Because PDE5 predominates in erectile tissue, systemic vasodilatory effects are typically modest at therapeutic doses. Nonetheless, vardenafil can synergize with exogenous NO donors, precipitating pronounced hypotension if nitrates or soluble guanylate-cyclase stimulators are co-administered. IA or class III anti-arrhythmic

agents (e.g., quinidine, procainamide, amiodarone, sotalol)

3. Dosage Forms, Administration, and Patient Considerations

One possibly serious, but rare, side effect with vardenafil is heart attack. Also, in rare cases, vardenafil use may cause priapism, a very painful emergency condition that can cause impotence if left untreated. In October 2007, the U.S. Food and Drug Administration (FDA) announced that a warning about possible deafness (sudden hearing loss) would be added to the drug labels of vardenafil, and other PDE5 inhibitors. Vardenafil should not be used by people taking nitrate medications, because combining them with vardenafil might provoke potentially life-threatening hypotension (low blood pressure).

Patients & Visitors

Further, vardenafil causes cenforce tablets lengthening of the QT interval. Therefore, it should not be taken by people taking other medications that affect the QT interval (such as amiodarone). Vardenafil was co-marketed by Bayer Pharmaceuticals, GlaxoSmithKline, and Schering-Plough under the brand name Levitra. As of 2005, the co-promotion rights of GSK on Levitra have been returned to Bayer in many markets outside the US. Thus, because of European Union trade rules, parallel imports might result in Vivanza sold next to Levitra in the EU.

Does vardenafil interact with other medicines (drug interactions)?

An orally disintegrating form, marketed as Staxyn and Levitra Soft, has been gaining approvals in countries such as the United States[11] and Canada. The US Food and Drug Administration (FDA) has found vardenafil and other synthetic PDE5 inhibitors in numerous products marketed as "herbal" supplements or "all natural" products for male enhancement. ^ a b c d "Levitra (vardenafil hydrochloride) tablets, for oral use Initial U.S. Approval: 2003". ^ "Levitra (Vardenafil) is A Drug Used to Treat Erectile Problems in Men" (in German). or in those fildena

^ "Staxyn - New Innovation in Erectile Dysfunction Helps Younger Men Rise to the Occasion". U.S. Food and Drug Administration (FDA). ^ Tucker J, Fischer T, Upjohn L, Mazzera D, Kumar M (October 2018). "Unapproved Pharmaceutical Ingredients Included in Dietary Supplements Associated With US Food and Drug Administration Warnings". purple pill with congenital long-QT syndrome.

• Vardenafil enhances blood flow to the penis.
• It is sold under brand names like Levitra and Staxyn.
• The drug is generally well-tolerated when used correctly.
• Common side effects include dizziness and nasal congestion.
• It should be stored in a cool, dry place away from children.
• Vardenafil is not an aphrodisiac; it requires sexual stimulation.
• Excessive doses can increase cardiovascular risks.
• It’s important to follow the doctor’s instructions for use.
• Patients with heart conditions should consult a doctor before use.
• Vardenafil may cause visual disturbances in some people.
• Regular medical review is recommended during treatment.